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BLEEDING RISK AMONG DRONEDARONE USERS ON CONCOMITANT TREATMENT WITH APIXABAN OR WARFARIN
Leif Friberg

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vol. 71 no. 11 Supplement A527
DOI:
https://doi.org/10.1016/S0735-1097(18)31068-4
Published By:
Journal of the American College of Cardiology
Print ISSN:
0735-1097
Online ISSN:
1558-3597
History:
Copyright Usage:
2018 American College of Cardiology Foundation

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Background

There is today no clinical published data about the potential increased bleeding risk due to interaction between dronedarone and NOACs. Although there is no recommendation against co-treatment with apixaban, the potential interaction has raised concerns among physicians. The aim was to study major bleedings in AF patients treated with dronedarone and either apixaban or warfarin.

Methods

Retrospective registry study using population wide Swedish health care registries. All patients with a diagnosis of nonvalvular AF between May 29, 2013 (when apixaban was introduced in Sweden) and December 31, 2015 and with concomitant treatmetn with either dronedarone-apixaban (n=1,423) or dronedarone-warfarin (n=3,010) were identified. Propensity score matching was used to create two similar cohorts each of 521 patients.

Results

In the propensity score matched cohorts, 6 patients on apixaban and 12 patients on warfarin suffered a major bleed leading to hospitlization or death. Corresponding rates were 1.3 and 1.7 per 100 years at risk respectively. No statistical significant difference in bleedings were seen between the cohorts.

Conclusion

The incidence of bleedings was very low in both cohorts and no significant differences were found between the regimes. There is nothing to indicate that co-treatment with apixaban and dronedarone should cause more bleeds that co-treatment with warfarin and apixaban.

Footnotes

Poster Contributions

Poster Hall, Hall A/B

Monday, March 12, 2018, 9:45 a.m.-10:30 a.m.

Session Title: Atrial Fibrillation: Outcomes and Management

Abstract Category: 08. Arrhythmias and Clinical EP: Supraventricular/Ventricular Arrhythmias

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